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Chemistry and Technology of Medicinal Substances, Part 1
Major: Pharmacy
Code of Subject: 6.226.01.E.77
Credits: 5
Department: Technology of Biologically Active Substances, Pharmacy and Biotechnology
Lecturer: : Professor, Dr.S. Vira Lubenets
Semester: 6 семестр
Mode of Study: заочна
Learning outcomes:
- know synthetic drug substance with effects on the central nervous system, which are used in modern medical practice;
- know the possible methods of obtaining of chemical active substances of synthetic drugs, technologies of major types of chemical reactions, which are used for the synthesis of drugs;
- be able to choose the best one method among the existing methods of synthesis, to check the quality of raw materials and, if necessary, purificate it up to the required standard;
- be able to carry out a stepwise synthesis of any drug substance with the required physical and chemical properties, and the degree of purification, with selection of optimal conditions, organize checked in laboratory conditions production of the drug in a production environment.
- know the possible methods of obtaining of chemical active substances of synthetic drugs, technologies of major types of chemical reactions, which are used for the synthesis of drugs;
- be able to choose the best one method among the existing methods of synthesis, to check the quality of raw materials and, if necessary, purificate it up to the required standard;
- be able to carry out a stepwise synthesis of any drug substance with the required physical and chemical properties, and the degree of purification, with selection of optimal conditions, organize checked in laboratory conditions production of the drug in a production environment.
Required prior and related subjects:
Prerequisites: Organic chemistry; Analytical Chemistry; Methods of organic synthesis; Pharmaceutical Chemistry;
Co-requisites: Medicines Quality Control, Industrial Technology of Pharmaceutical Manufactures, The Scientific Aspects of Ecology of Chemical and Pharmaceutical Production
Co-requisites: Medicines Quality Control, Industrial Technology of Pharmaceutical Manufactures, The Scientific Aspects of Ecology of Chemical and Pharmaceutical Production
Summary of the subject:
Chemistry and technology of medicinal substances with effects on the central nervous system (anesthesia, local anesthetic, hypnotics, anticonvulsants agents), psychotropic drugs (neuroleptics, tranquilizers, nootropic substances and stimulating the central nervous system agents), analgesics (narcotic analgesics, non-narcotic analgesics and nonsteroidal anti-inflammatory substances).
Recommended Books:
1. Ол. Швайка. Основи синтезу лікарських речовин та їх проміжних продуктів. Вид. друге, виправлене й доповнене, Донецьк, 2004.
2. Р.С.Вартанян. Синтез основних лекарственних средств. МИА Москва, 2004.
3. В.О.Ковтуненко. Лікарські засоби з дією на центральну нервову систему. Вид.-торгова фірма “Перун “Київ-Ірпінь,1997.
4.Л.С.Майофис. Химия и технология химико-фармацевтических препаратов. М.:Медицина, 1964.
5 Л.Н. Яхонтов, Р.Г. Глушков Синтетические лекарственные средства. М.:Медицина, 1983
2. Р.С.Вартанян. Синтез основних лекарственних средств. МИА Москва, 2004.
3. В.О.Ковтуненко. Лікарські засоби з дією на центральну нервову систему. Вид.-торгова фірма “Перун “Київ-Ірпінь,1997.
4.Л.С.Майофис. Химия и технология химико-фармацевтических препаратов. М.:Медицина, 1964.
5 Л.Н. Яхонтов, Р.Г. Глушков Синтетические лекарственные средства. М.:Медицина, 1983
Assessment methods and criteria:
- thematic test control and written individual tasks - 40 points
- final control (control measure, exam) - 60 points (written-oral form
- final control (control measure, exam) - 60 points (written-oral form