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Chemistry 2 (Organic Chemistry), Part 1

Major: Biotechnology and bioengineering
Code of Subject: 6.162.00.O.5
Credits: 3.5
Department: Organic Chemistry
Lecturer: Orest Hevus
Semester: 1 семестр
Mode of Study: заочна
Learning outcomes:
The purpose and tasks of the discipline
1. The purpose of studying the discipline
The discipline "Organic Chemistry" belongs to the fundamental disciplines, the purpose of which is to familiarize students with the classification of organic compounds and the peculiarities of their chemical behavior of organic compounds, the theory and practice of organic synthesis.
In preparation of bachelors, specialists and masters of the specialty "Chemical technologies and bioengineering" serves as the main discipline, which forms the basis for further study of bioorganic chemistry and technology of biotechnological processes.
The study of the course "Organic Chemistry" requires some prior chemical preparation and knowledge of the structure of the atom, the periodic system of elements and the basis of the structure of substances. Therefore, "Organic Chemistry" is studied after the course "General and Inorganic Chemistry" or in parallel with this course. Study program material will be carried out through interconnected forms of training: lectures, laboratory workshops and independent work of students.

2. Tasks of the discipline
Study of the discipline involves the formation and development of students of competencies:
general:
• Skills to perform safe laboratory activities;
• Ability to work individually and in a team;
• the ability to use information and telecommunication technologies to obtain information on organic matter.
professional:
• the ability to use sound knowledge of organic chemistry to the extent necessary for the mastering of general engineering and professionally oriented disciplines;
• have laboratory skills and ability to perform experimental research;
• have the ability to learn new knowledge independently.

Learning outcomes of this discipline detail the following programmatic learning outcomes:
• theoretical knowledge of the structure of organic substances of synthetic and natural origin;
• theoretical knowledge of the interconnection of the structure of organic substances with their physical and chemical properties;
• theoretical knowledge of the basic approaches to the synthesis of organic substances and the study of their properties;
• practical skills in synthesis and research of properties of substances in a chemical laboratory;
• knowledge of safety rules and the acquisition of safe techniques in the chemical laboratory.
Required prior and related subjects:
Chemistry (high school)
Physics (High School)
General and inorganic chemistry
Methods of organic synthesis
Chemistry of natural biologically active compounds
Chemistry of carcinogens
Molecular Biology
Summary of the subject:
The course "Organic Chemistry" is devoted to the study of the basics of the modern theory of the chemical structure of organic substances, as well as the basic industrial and laboratory methods for obtaining the basic classes of organic compounds, their physical and chemical properties. Particular attention is paid to the study of the relationship between the chemical structure of substances and their physical and chemical properties, the ability to predict the course of the most important chemical reactions, based on their mechanisms, to study the basic principles of modern classification and nomenclature of organic compounds. A significant place in the course is given to the study of the classes of organic compounds necessary for the mastering of the discipline "Biological Chemistry and Molecular Biology" Lecture classes - 32 hours 1. Semantic module 1. Subject of organic chemistry. Theoretical representations in organic chemistry - 10 hours 1. 1. Introduction - - 2 hours The subject of organic chemistry and the stages of its development. The main raw materials of organic compounds. Environmental Issues and Environmental Protection. 1.2. Theoretical representations in organic chemistry - 8 hours Development of theoretical representations in organic chemistry. Acidity and basicity of organic compounds. Types of isomerism of organic compounds. Classification of reactions of organic compounds and reagents. The notion of intermediates in organic reactions. Basic functional groups and classification of organic compounds. 2. Content module 2. Aliphatic hydrocarbons and their halogenated, sulphonated and nitro derivatives - 12 hours 2.1. Aliphatic hydrocarbons - 7 hours 2.1. Alkanes (saturated hydrocarbons, paraffins) -2 hours. Homologous series of alkanes. The notion of the alkali. IUPAC Nomenclature for alkanes. Methods of preparation, physical and chemical properties. 2.2. Alceny - 2 hours Homologous series. Nomenclature, structural and spatial isomerism. Methods of extraction, physical and chemical properties. The concept of vinyl monomers and macromolecular compounds. 2.3. Aladdin - 1 hour Methods of extraction, physical and chemical properties. Natural and synthetic rubbers. Rubber. 2.4. Alkin - 2 hours. Methods of extraction, physical and chemical properties of alkenes. Vinylacetylene and divinylacetylene. Polymerization of acetylene, Industrial synthesis based on acetylene. 2.5. Halogenated hydrocarbons -2 h. 2.5.1. Halogenated saturated hydrocarbons. Mono- and polyhalogen-derivatives. Methods of obtaining, physical and chemical properties of halogenated saturated hydrocarbons. Freoni 2.5.2. Halogenated unsaturated hydrocarbons. - 1 year Vinyl chloride, allyl chloride and chloroprene. Polyvinyl chloride and plastics on its base. Teflon Chloroprene rubber 2.6. Nitrogen-containing compounds - 2 hours 2.6.1. Aliphatic nitro compounds. Methods of preparation, physical and chemical properties of nitro compounds. Use of nitro compounds in engineering. 2.6.2. Aliphatic amines. Methods of preparation, physical and chemical properties of amines. Quaternary ammonium bases and salts, their use. Diamonds. Polyamides 3. Content module 3. Oxygen-containing compounds (10 h) 3.1.1. Monohydric alcohols - 2 hours  Nomenclature, methods of obtaining, physical and chemical properties of alcohols. Methyl, ethyl, propyl, allyl and propargyl alcohols. 3.1.2. Multi-atomic alcohols - 1 hour  Glycols, glycerol, pentaerythral .. Getting, physical and chemical properties .. Application in industry. Fat., Lipids. 3.2. Ethers and peroxides - 1 hour. 3.2.1. Eteri, Methods of their obtaining, physical and chemical properties. Cyclic ethers. Crown Eaters 3.2.2. Organic peroxides. Classification, extraction and properties of organic peroxides. Their application as initiators. free radical reactions 3.3. Aldehydes and ketones - 3 hours. 3.3.1. Saturated aldehydes and ketones. Structure, isomerism, nomenclature. Methods of preparation, physical and chemical properties. Anthrax aldehyde, acetic aldehyde, paraform, paraldehyde. Chlorine, acetone. 3.3.2. Unsaturated aldehydes and ketones. Acrolein, vinyl methyl ketone. Kentini Structure, Obtaining, Properties and Applications. 3.3.3. Di-aldehydes and diketones. Glioksal, diacetyl, acetylacetone. 3.4. Carboxylic acids. - 3 hours 3.4. 1. Single-base saturated carboxylic acids -2 hours. Structure, methods of obtaining and charming properties of carboxylic acids. Higher carboxylic acids. Sweetheart 3.4.2. Unsaturated monobasic carboxylic acids: acrylic, methacrylic, crotonic vinyl acetate. Polymerization and copolymerization. Cis-, trans-isomerism of acids. Fats and oils, their structure and composition. Waxes  3.4.3. Two-base carboxylic acids. Structure, isomerism, nomenclature. Technical methods of their obtaining, properties and applications. Malonyi ester, adipic and sebacic acid. Fiber anid (nylon). Two-base unsaturated acids. Malein and fumaric acid, production and properties. Maleic anhydride and its use. 3.4.4. Carboxylic acid and its derivatives: hydrochloric acid and its esters. Polyurethanes Carbamide, urea resins. Seminars and laboratory works 1.Technika of laboratory works and safety equipment in the chemical laboratory. 2. Methods of separation and purification of organic compounds. Distillation with steam, extraction and recrystallization. 3. Types of chemical bonds in organic compounds: ionic, covalent, donor-acceptor, hydrogen bonds. Quantum-mechanical notions about the nature of s- and p-bonds. Types of carbon atrophy of a carbon atom. The main characteristics of the covalent bond of the carbon atom. Methods of "Valency Relations" (VZ) and "Molecular Orbits" (MO). 4. Mutual influence of atoms in a molecule. Induction and mesomeric effects. Effect of oversaturation (hyperconjugation). Structural theory of the structure of organic compounds. Isomerism of organic compounds. Test 1 5. Stereochemical representations in organic chemistry. Spatial isomerism, its species. Test 2 6. Types of organic reactions and their mechanisms. Intermediate particles formed under reaction conditions: free radicals, carbocations, carbanions. Their electronic characteristics and the relationship between structure and stability. Attacking agents in chemical reactions: electrophiles, nucleophiles, free radicals. Acidity and basicity of organic compounds. Test 3 7. Colloquium 1. Structure and reactivity of organic compounds (14 points) 8. Alkani Alkeny The structure Isomerism Methods of obtaining. Chemical properties. 9. Alcadia. Alkini The structure Isomerism Methods of obtaining. Chemical properties. Test 4 10. LR 2. Study of chemical properties of aliphatic hydrocarbons. 11. Halogenated hydrocarbons. Methods of obtaining. Chemical properties. Mechanisms of nucleophilic substitution reactions (SN1 and SN2). Test 5 12. Mono-, di- and polyhydric alcohols. Ether Peroxides Preparation and chemical properties. 13. Aldehydes, ketones. Preparation and chemical properties. 14. LR 3. Study of chemical properties of aliphatic alcohols, ethers, aldehydes, ketones and carboxylic acids. 15. Colloquiums 2. Saturated and unsaturated aliphatic hydrocarbons, their halogen derivatives, alcohols, ethers, peroxides and carbonyl compounds (14 points) 16. Aliphatic sulfur-containing compounds, nitro compounds and amines. Test 6
Recommended Books:
Basic
1. Yu.O.Lastukhin, S.A.Voronov. Organic Chemistry. Kind. "Center of Europe". 2004
2. Dombrovsky VI, Naidan VM Organic Chemistry. -K .; senior lecturer, 1992.
3. Petrov AA, Bal'yan AV, Troshchenko A.T. Organic chemistry. - Moscow: "Higher school." - 1981.
4. Neiland O.E. Organic chemistry. - Moscow: "Higher school." - 1990.
5. Ternei A. Modern Organic Chemistry (in two books). Per. with English, - M .: Peace. 1981
6. Morrison R., Boyle R. Organic chemistry. -M .: the world. 1974
7. Sykes P. Mechanisms of organic reactions. -M .: Chemistry. 1991
8. Litkovets O.K. Organic chemistry for self-training students. h 1 and 2

Auxiliary
1. Chernykh VP, Zimenkovsky BS, Gritsenko IS Organic chemistry (in three books) .- Kharkiv, "Basis". 1996
2. Litkovets O.K., Pokhmurskaya M.V. Polymer compounds. DULP 1996
3. May VF Electronic structure and properties of organic molecules. - Moscow: "Higher school." - 1989.
4. Nekrasov V.V. Guide to the Small Workshop on Organic Chemistry. - M .: Chemistry. 1985
5. Organic. Workshop on Organic Chemistry. In 2 volumes. -M .: 1992.
Assessment methods and criteria:
Methods of diagnosing knowledge:
1. Current control: colloquiums, control work, tests.
2. Semester control: exam

Criteria for evaluating student outcomes
1.Current control (PC):
Colloquium 1 -1 4 points
Colloquium 2 -14 points
Laboratory work:
LR-1 -2 points
ЛР-2 - 2 points
ЛР-3 - 2 points
Tests:
T1 - 1 point
T2 - 1 point
T3 - 1 point
T4 - 1 point
T5 - 1 point
T6 - 1 point
Total for PC: - 40 points
Exam:
written component - 50 points
oral component -10 points
Total -100 points