• Knowledges of modern physicochemical methods of identification of organic compounds, medicinal substances and pharmaceuticals;
• Knowledges of metabolism of biologically active compounds in the human body in order to interpret the mechanism of their action at the molecular level for the development of new drugs.
• Ability to interpret the relationship of the electronic and spatial structure of organic compounds with their reactivity and physicochemical properties;
• Ability to pick up basic approaches to fine synthesis and separation of organic substances and to apply physicochemical methods to identify them.

Prerequisites:
• Biochemistry and molecular biology
• Pharmacokinetics
• Fundamentals of pharmacotherapy
Co-requisites:
• Clinical and pharmaceutical aspects of drug using (special course, part 3)

Relation of physicochemical properties of biologically active compounds with their pharmacological activity. Drug-receptor interaction. Metabolism of biologically active substances. Metabolic pathways and sites of metabolic changes of xenobiotics. Transport of drugs through membranes. Relationship of structure and degree of metabolism of medicinal substances. Biochemical transformation of medicinal substances in the body. Factors that affect drug metabolism.

1. N.H.Мarintsova, S.V. Polovkovych, V.P.Novikov. Biological chemistry. –L.:Lviv Polytechnic National University, 2013. -336 p.
2. V.D Orlov, V.V. Lipson, V.V. Ivanov. Medical chemistry. - Kharkov, Folio, 2005. - 461 p.
3. R. Marry, D. Granner, P. Meyes, and V. Rodwell. Human biochemistry in 2 volumes. - Moscow, Mir
4. S. Angelsky, M.G. Dominiczak, Z. Jakubowski. Clinical biochemistry. - Sopot, Perseus, 2000. - 451 p.

• Written reports on laboratory works – 10 points;
• Summary control - 90 points ( control, exam): written-oral form.